About TRINTELLIX

Information about TRINTELLIX

What is TRINTELLIX used for?

TRINTELLIX is used for treatment of depression in adults (18 years of age or older). It is used to relieve the symptoms of depression, which may include:

Feeling sad
Restless
Irritable
Change in weight or appetite
Having a hard time concentrating or sleeping
Feeling tired
Headaches
Unexplained aches and pains

How does
TRINTELLIX work?

TRINTELLIX is thought to work by correcting the imbalance of serotonin in your brain. This may help ease emotional and physical symptoms of depression.

Taking TRINTELLIX

How do I take TRINTELLIX?

It is very important that you take TRINTELLIX exactly as your doctor or pharmacist
has instructed.

Take one TRINTELLIX tablet with a glass of water, with or without food.
The usual adult dose is 10 mg once daily, for adults 18 to 64 years of age.
Depending on how you respond, your doctor may increase your maximum dose to 20 mg per day or decrease your minimum dose to 5 mg per day.
For patients 65 years of age and over, the usual starting dose is 5 mg once daily.
Do not suddenly stop taking TRINTELLIX or change the dose without talking with your doctor first.
Continue to take TRINTELLIX for as long as your doctor recommends.
If you miss a dose of TRINTELLIX, you do not need to make up the missed dose. Skip the missed dose and continue with your next scheduled dose. Do not take two doses at the same time.

5 mg TRINTELLIX pill 10 mg TRINTELLIX pill 20 mg TRINTELLIX pill

How long do I need to take TRINTELLIX?

Everyone responds to medications differently, so it’s important for you to work with your doctor and medical team and communicate how you’re feeling while you’re taking TRINTELLIX.

Did you know?

Canadian treatment guidelines for depression recommend that people stay on antidepressants for 6 to 24 months, or longer. Continue to take TRINTELLIX for as long as your doctor recommends.

Possible side effects

What can I expect when taking TRINTELLIX?

Serious Warnings and Precautions

New or worsened emotional or behaviour problems:

When you first start taking TRINTELLIX or when your dose is adjusted, you may feel worse instead of better. You may feel new or worsened feelings of agitation, hostility, anxiety, or impulsivity.
During your treatment with TRINTELLIX, it is important that you and your healthcare professional talk regularly about how you are feeling. They will closely monitor you for signs of new or worsened emotions or behaviours while you are taking TRINTELLIX.
You may find it helpful to tell a relative or close friend that you are depressed. Ask them to read this leaflet. You might ask them to tell you if they:
1. - think your depression is getting worse, or
2. - are worried about changes in your behaviour.
If your depression worsens or you experience changes in your behaviour, tell your healthcare professional right away. Do not stop taking your medicine as it takes time for TRINTELLIX to work.

Self-harm or Suicide:

Antidepressants, such as TRINTELLIX, can increase the risk of suicidal thoughts or actions.
If you have thoughts of harming or killing yourself at any time, tell your healthcare professional or go to a hospital right away. You will be closely observed by your healthcare professional in this situation.

The most common side effects of TRINTELLIX are:

Abdominal pain, bloating
Common cold, Influenza (flu) symptoms
Nausea, vomiting
Decreased appetite
Abnormal dreams and difficulty sleeping
Dizziness
Dry mouth
Diarrhea, constipation
Fatigue, sleepiness
Sedated (feeling calm)
Body feels itchy
Joint and muscle pain
Increase in sweating
Cough

Other possible side effects of TRINTELLIX may include:

Abnormal excessive sweating
Dry eye
Grinding teeth
Headache
Reddening of skin
Night sweats
Weight gain
Muscle twitching
Yawning
Dehydration
Late menstrual cycle (period) and sensitive breasts
Sexual problems (decreases in sexual desire, performance and satisfaction, may also lead to further decreases, which may continue after the drug is stopped)

These are not all the possible side effects you may feel when taking TRINTELLIX. If you experience any side effects not listed here, contact your healthcare professional.

Symptom Tracker

Keep track of your treatment journey

When you’re taking TRINTELLIX, it’s important that you and your doctor have good communication about how you’re feeling. Keeping track can help.

Use our symptom tracker to record how you’re feeling, and then bring it to your doctor’s appointment.

Download Symptom Tracker